Description

2,5-Dihydro-2-Hydroxy-5-Nitro-2-Furanmethanediol-D3 Triacetate is a deuterium-labeled, nitro-substituted furan derivative designed for high-precision isotopic tracing in pharmaceutical and agrochemical research. Its structural stability under controlled conditions and defined deuterium incorporation (D3) enable accurate metabolic pathway mapping and kinetic isotope effect (KIE) studies. This compound is essential for R&D laboratories requiring analytically traceable, chemically robust internal standards in LC-MS/MS and NMR-based assays. It serves global clients in drug discovery, analytical method development, and regulatory bioanalysis.

Application

• Internal standard for quantitative LC-MS/MS analysis of nitrofuran metabolites in biological matrices (urine, plasma, tissue)
• Isotopic tracer in mechanistic studies of nitroreductase enzyme activity and bacterial metabolism
• Reference material for validation of residue testing methods in food safety monitoring (e.g., EU Commission Decision 2002/657/EC)
• Synthetic intermediate in the preparation of deuterated pharmacophores for ADME (Absorption, Distribution, Metabolism, Excretion) profiling
• Calibration standard for forensic toxicology labs conducting nitrofuran residue screening in aquaculture and poultry products
• Tool compound in radiolabel-free metabolic stability assays during preclinical candidate selection

Basic Information

Product Name	2,5-Dihydro-2-Hydroxy-5-Nitro-2-Furanmethanediol-D3 Triacetate
CAS No.	1346604-22-5
Molecular Formula	C10H9D3N1O8
Molecular Weight	279.20 g/mol
Synonyms	2,5-Dihydro-2-hydroxy-5-nitro-2-furanmethanediol-d3 triacetate; 2-(Acetyloxy)-2-[(acetyloxy)methyl]-5-nitro-2,5-dihydrofuran-2-ol-d3; Triacetyl-d3-hydroxynitrofuran diol; D3-labeled nitrofuran triacetate; 2,5-Dihydro-5-nitro-2-(hydroxymethyl)-2-furanol-d3 triacetate; NSC 754899-d3; Nitrofuran-d3 triacetate; 2,5-Dihydro-2-hydroxy-5-nitrofuran-2-yl-d3 triacetate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for isotopic purity (≥99.0% D-incorporation at designated positions), chemical purity (≥98.5% by HPLC), and absence of critical impurities (e.g., residual solvents, heavy metals, and unreacted precursors). Testing adheres to ICH Q5, Q7, and USP <1225> guidelines for reference standards used in regulated bioanalytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	Pale yellow to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5% – 101.0%
Isotopic Purity (MS)	≥99.0% D3 incorporation
Related Substances (HPLC)	≤0.5% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.