Description

Rac Diacetolol-D7 is a deuterium-labeled internal standard of the β-blocker metabolite diacetolol, specifically designed for analytical applications. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical, contract research, and forensic toxicology laboratories for method development, validation, and routine testing.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, isotopically labeled reference compound for the precise quantification of diacetolol and related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) for acebutolol and its active metabolite, diacetolol.
• Bioanalytical Method Development: Used to establish and validate robust, sensitive, and selective analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Doping Control and Forensic Analysis: Supports the detection and confirmation of β-blocker use in sports drug testing and forensic investigations.
• Clinical Research: Facilitates therapeutic drug monitoring and clinical study sample analysis to correlate drug levels with efficacy and safety outcomes.
• Quality Control in Pharmaceutical Manufacturing: Assays for potential impurities or degradation products in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Rac Diacetolol-D7
CAS No.	1346604-19-0
Molecular Formula	C18H21D7N2O5
Molecular Weight	Contact for details
Synonyms	Diacetolol-d7; 3'-Acetyl-4'-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]butyranilide-d7; N-[3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]butyramide-d7; Acebutolol Metabolite Diacetolol-d7; (±)-Diacetolol-d7; Rac-Diacetolol-d7; Diacetolol (deuterated)
EINECS	Contact for details

Quality Control

Our Rac Diacetolol-D7 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment, chemical purity, and confirming identity. We support research requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.