Description

Aripiprazole-D8 N,n-Dioxide is a deuterated internal standard of a key pharmaceutical intermediate, specifically designed for high-precision analytical applications. This compound is essential for ensuring accurate quantification and method validation in complex matrices, providing superior reliability for research and quality control. It is primarily utilized by analytical laboratories, pharmaceutical R&D departments, and CROs engaged in the development, metabolism studies, and impurity profiling of neuropsychiatric drugs.

Application

• Internal Standard for LC-MS/MS: Used as a critical reference compound in quantitative bioanalysis for pharmacokinetic and pharmacodynamic studies.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.
• Metabolite Identification & Research: Serves as a stable isotope-labeled tracer in drug metabolism and disposition studies to track metabolic pathways.
• Method Development & Validation: Provides a stable, non-interfering standard for developing and validating robust analytical methods (HPLC, UPLC).
• Quality Control & Assurance: Employed in GMP/GLP environments to ensure batch-to-batch consistency and compliance of the parent drug substance.
• Forensic & Clinical Toxicology: Supports accurate measurement of aripiprazole and related compounds in biological samples for forensic analysis.

Basic Information

Product Name	Aripiprazole-D8 N,n-Dioxide
CAS No.	1346603-98-2
Molecular Formula	C23H19D8Cl2N3O3
Molecular Weight	466.42 g/mol
Synonyms	7-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone-D8 N,N-Dioxide; Aripiprazole D8 N-Oxide; Deuterated Aripiprazole N-Oxide; Aripiprazole-d8 N,N'-Dioxide; OPC-14597-d8 N-Oxide; Abilify-d8 Metabolite Standard; 3,4-Dihydro-2(1H)-quinolinone-3,5,6,7,8-d8, 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-, 1,1-dioxide
EINECS	Contact for details

Quality Control

Our Aripiprazole-D8 N,n-Dioxide is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for chemical purity, isotopic purity (D-enrichment), and identity confirmation via spectroscopic methods. We adhere to relevant industry standards for reference materials to ensure reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.