Description

4-(Bromomethyl)-2,2-Dimethyl-1,3-Dioxolane-D5 is a deuterium-labeled protected bromoacetal derivative widely used as a stable isotopic building block in medicinal chemistry and radiopharmaceutical synthesis. Its deuterated structure (D5) provides enhanced metabolic stability and enables precise tracking in pharmacokinetic and mechanistic studies. This compound is essential for researchers developing next-generation PET tracers, kinase inhibitors, and covalent drug candidates requiring isotopic fidelity and controlled reactivity. It serves pharmaceutical R&D laboratories, contract research organizations (CROs), and radiochemistry facilities engaged in late-stage functionalization and isotopic labeling.

Application

• Deuterium-labeled intermediate for synthesis of PET imaging agents (e.g., [¹⁸F]- or [¹¹C]-labeled analogs)
• Stable isotopic probe in ADME (Absorption, Distribution, Metabolism, Excretion) studies of acetal-containing drug candidates
• Building block for covalent PROTACs and molecular glues where controlled alkylation of nucleophilic residues (e.g., cysteine) is required
• Synthesis of deuterated analogs of bioactive molecules containing 1,3-dioxolane motifs (e.g., antiviral nucleoside derivatives)
• Chemoselective alkylation reagent in complex molecule synthesis under mild acidic or thermal deprotection conditions
• Isotopic internal standard for quantitative LC-MS/MS bioanalysis of dioxolane-based therapeutics

Basic Information

Product Name	4-(Bromomethyl)-2,2-Dimethyl-1,3-Dioxolane-D5
CAS No.	1346603-73-3
Molecular Formula	C₆H₇BrD₅O₂
Molecular Weight	219.08 g/mol
Synonyms	4-(Bromomethyl)-2,2-dimethyl-1,3-dioxolane-1,1,2,2,3-d₅; 4-(Bromomethyl)-2,2-dimethyl-[1,3-¹³C₂]dioxolane-D5; Bromomethyl-dimethyl-dioxolane-D5; D5-BMD; Deuterated bromomethyl dioxolane; 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxolane-3,3,4,4,5-d₅; CAS 1346603-73-3; BMD-D5
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for isotopic enrichment (≥98% D incorporation by ²H NMR), chemical purity (≥98.5% by HPLC), and structural identity (IR, ¹H/²H/¹³C NMR). All materials are manufactured under ISO 9001-certified processes and comply with REACH regulations. For pharmaceutical applications, GMP-aligned documentation and traceability are available on request.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C under dry, inert atmosphere (argon or nitrogen) due to hygroscopic nature. Keep away from moisture and direct sunlight. Ensure adequate ventilation in storage areas.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Assay (HPLC)	≥98.5%
Isotopic Purity (²H NMR)	≥98% D-incorporation
Water Content (KF)	≤0.1%
Residue on Ignition	≤0.1%
Identification (IR)	Conforms to reference spectrum
Identification (¹H NMR)	Conforms to reference spectrum
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.