Description

n-Nitrosodiethylamine-D4 is a stable isotope-labeled analog of the nitrosamine compound n-Nitrosodiethylamine (NDEA). This deuterated standard is essential for achieving high accuracy and reliability in quantitative analytical methods, particularly mass spectrometry. It is primarily used by analytical laboratories and research institutions in the pharmaceutical, environmental, and food safety sectors for method development, calibration, and as an internal standard to ensure precise measurement of its non-labeled counterpart, a known potent carcinogen.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference in LC-MS/MS and GC-MS analysis for accurate determination of n-Nitrosodiethylamine (NDEA) levels.
• Pharmaceutical Impurity Testing: Used in the development and validation of analytical methods to monitor and control nitrosamine impurities (e.g., NDEA) in active pharmaceutical ingredients (APIs) and finished drug products, ensuring compliance with regulatory guidelines (e.g., FDA, EMA).
• Food and Beverage Safety Analysis: Employed in testing for nitrosamine contaminants in food products, such as cured meats and certain beers, to assess consumer exposure risks.
• Environmental and Toxicological Research: Facilitates precise tracking, metabolism studies, and environmental fate analysis of NDEA in complex biological and ecological matrices.
• Method Development and Validation: A key reagent for establishing specificity, accuracy, and precision in new analytical protocols for nitrosamine detection.
• Quality Control and Assurance: Supports high-purity calibration standards for routine quality control testing in analytical laboratories.

Basic Information

Product Name	n-Nitrosodiethylamine-D4
CAS No.	1346603-41-5
Molecular Formula	C4D8N2O
Molecular Weight	120.17 g/mol
Synonyms	NDEA-d4; N-Nitrosodiethylamine-d4; Diethylnitrosamine-d4; N,N-Diethylnitrosamine-d4; NDEA-d8 (common designation for perdeuterated ethyl groups); Deuterated N-Nitrosodiethylamine; [2H8]-N-Nitrosodiethylamine; Internal Standard for NDEA
EINECS	Contact for details

Quality Control

Every batch of n-Nitrosodiethylamine-D4 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters including isotopic purity (D-content), chemical purity (by HPLC or GC), and identity confirmation (by NMR and MS). Our quality commitment ensures the material meets the stringent requirements for use as a certified reference material in regulated analytical environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from strong acids and oxidizing agents. For long-term storage, consider storing under inert atmosphere at lower temperatures (e.g., -20°C) to maximize stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC/GC)	≥ 98% (Chemical Purity)
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.