Description

2-[2-(Dimethylamino)Ethyl]-1-Indanone-D6 is a deuterated small-molecule compound featuring selective deuterium labeling at six positions (D6), designed to enhance metabolic stability and improve pharmacokinetic profiling in drug discovery research. This isotopically enriched derivative serves as a critical reference standard and internal standard for quantitative LC-MS/MS bioanalysis of its non-deuterated counterpart and related amine-containing indanone pharmaceutical candidates. It is primarily utilized by medicinal chemists, analytical method developers, and preclinical CMC teams in global pharmaceutical and contract research organizations.

Application

• Internal standard for LC-MS/MS quantification of 2-[2-(dimethylamino)ethyl]-1-indanone and structurally related CNS-active compounds in biological matrices (plasma, urine, tissue)
• Metabolic stability assessment in hepatocyte and microsomal incubation studies
• Pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) profiling during lead optimization
• Reference material for method validation per FDA/ICH M10 and EMA bioanalytical guidelines
• Synthesis intermediate for deuterated analogues in structure–activity relationship (SAR) exploration
• Calibration standard in high-sensitivity quantitative assays targeting monoamine transporter modulators

Basic Information

Product Name	2-[2-(Dimethylamino)Ethyl]-1-Indanone-D6
CAS No.	1346603-38-0
Molecular Formula	C13D6H13NO
Molecular Weight	225.32 g/mol
Synonyms	2-(2-(Dimethylamino)ethyl)-1-indanone-d6; N,N-Dimethyl-2-(1-oxo-2,3-dihydro-1H-inden-2-yl)ethanamine-d6; D6-2-(2-Dimethylaminoethyl)indanone; 2-[2-(Dimethylamino)ethyl]-2,3-dihydro-1H-inden-1-one-d6; 2-(2-(Dimethylamino)ethyl)indanone-1,1,2,2,3,3-d6; NSC 171951-d6; Indanone, 2-(2-(dimethylamino)ethyl)-, d6
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for isotopic enrichment (>98% D-incorporation at designated positions), chemical purity (≥98.5% by HPLC), and structural identity (NMR, IR, MS). Testing adheres to ICH Q5B, Q7, and USP <1225> guidelines for reference standards used in regulated bioanalysis.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C under inert atmosphere (argon or nitrogen) to prevent degradation. Keep away from moisture and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to reference 1H- and 2H-NMR spectra
Assay (HPLC)	≥98.5%
Isotopic Purity (MS)	≥98% D6 incorporation
Residual Solvents (GC)	Meets ICH Q3C limits
Water Content (Karl Fischer)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.