Description

2-Chloro Fenofibric Acid-D6 is a stable isotope-labeled analog of the active metabolite of fenofibrate, a widely used lipid-regulating agent. This high-purity deuterated standard is critical for ensuring accuracy and reliability in quantitative bioanalytical methods. It is an essential tool for pharmaceutical R&D and clinical laboratories engaged in pharmacokinetic studies, drug metabolism research, and therapeutic drug monitoring. The compound provides the internal standard necessary for precise LC-MS/MS analysis, eliminating variability and enhancing data integrity.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in the bioanalysis of fenofibric acid and related compounds in biological matrices.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Therapeutic Drug Monitoring (TDM): Used in clinical laboratories to develop robust assays for monitoring patient plasma levels of fenofibrate therapy.
• Method Development & Validation: Serves as a critical reference material for developing, optimizing, and validating new analytical methods in compliance with GLP/GCP guidelines.
• Impurity Profiling & Characterization: Aids in the identification and quantification of process-related impurities or degradants in active pharmaceutical ingredient (API) batches.
• Reference Standard for Regulatory Submissions: Provides the certified material required for supporting regulatory filings (e.g., FDA, EMA) for new drug applications.

Basic Information

Product Name	2-Chloro Fenofibric Acid-D6
CAS No.	1346603-06-2
Molecular Formula	C17H9D6ClO4
Molecular Weight	324.76 g/mol
Synonyms	2-Chloro-4-(4-chlorobenzoyl)phenoxy-2-methylpropionic-d6 Acid; Deuterated Fenofibric Acid Derivative; [2H6]-2-Chloro Fenofibric Acid; Isotopic Labeled Fenofibric Acid Metabolite; 2-Methyl-2-{[4-chloro-3-(trideuteriomethyl)phenoxy]carbonyl}phenoxy-2,2-d2-propanoic-3,3,3-d3 Acid; D6-Fenofibric Acid Chloro Analog; Internal Standard for Fenofibric Acid Analysis
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro Fenofibric Acid-D6 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing isotopic purity, chemical purity, and confirming the absence of interfering unlabeled species.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. For long-term storage, keep the container in a cool, dry, well-ventilated area. Handle and store in accordance with good laboratory practice.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (NMR/MS)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.