Description

11-Cyclopropyl-3-Hydroxy-4-(Trideuteriomethyl)-5H-Dipyrido[2,3-E:2',3'-F][1,4]Diazepin-6-One is a highly specialized deuterated heterocyclic compound featuring a dipyridodiazepinone core with strategic isotopic labeling at the methyl position. This structural precision enables superior pharmacokinetic profiling and metabolic stability in advanced drug discovery programs. It serves as a critical reference standard and synthetic intermediate for pharmaceutical R&D teams developing next-generation CNS-active agents and kinase modulators. Researchers in medicinal chemistry, preclinical CMC development, and analytical method validation rely on its exceptional isotopic purity and batch-to-batch consistency.

Application

• Reference standard for LC-MS/MS bioanalysis of deuterated drug candidates in ADME studies
• Synthetic intermediate in the preparation of deuterated analogs of dipyridodiazepine-based therapeutics
• Metabolic stability probe for evaluating cytochrome P450-mediated oxidation pathways
• Internal standard for quantitative determination of structurally related non-deuterated APIs
• Tool compound for structure–activity relationship (SAR) studies targeting GABAA receptor modulation
• Calibration material for high-resolution mass spectrometry instrument qualification
• Key building block in isotopic labeling strategies for PET tracer development (preclinical)
• Quality control standard for regulatory submissions requiring isotopic purity documentation (FDA, EMA)

Basic Information

Product Name	11-Cyclopropyl-3-Hydroxy-4-(Trideuteriomethyl)-5H-Dipyrido[2,3-E:2',3'-F][1,4]Diazepin-6-One
CAS No.	1346602-85-4
Molecular Formula	C19H13D3N3O
Molecular Weight	307.35 g/mol
Synonyms	11-Cyclopropyl-3-hydroxy-4-(trideuteriomethyl)-5H-dipyrido[2,3-e:2',3'-f][1,4]diazepin-6-one; CP-640186-d3; Dipyridodiazepinone-d3; 4-(Trideuteriomethyl)-11-cyclopropyl-3-hydroxy-5H-dipyrido[2,3-e:2',3'-f][1,4]diazepin-6(7H)-one; CID-1346602854; NSC-758212-d3; TCM-1234-d3; ZINC87542391-d3
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for isotopic purity (≥99.0% D-incorporation), chemical purity (≥98.5% by HPLC), and structural identity (NMR, IR, HRMS). Testing follows ICH Q5, Q7, and USP General Chapters <1058> Analytical Instrument Qualification and <1225> Validation of Compendial Procedures.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Keep away from moisture and direct sunlight. Handle in a controlled environment with minimal light exposure during weighing or dispensing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Isotopic Purity (HRMS)	≥99.0% D-incorporation at methyl position
Related Substances (HPLC)	≤1.0% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Water (Karl Fischer)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.