Description

5-Fluoro Paliperidone-D4 is a deuterated analog of the antipsychotic drug paliperidone, specifically labeled with four deuterium atoms and a fluorine substitution. This compound is a critical stable isotope-labeled internal standard used in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on neuropharmacology and drug development.

Application

• Primary use as a stable isotope-labeled internal standard for the precise quantification of paliperidone and its metabolites in biological matrices via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies for generic and novel antipsychotic drug formulations.
• Enables accurate metabolite profiling and drug metabolism studies in preclinical and clinical research settings.
• Supports forensic and clinical toxicology analyses for monitoring drug levels and ensuring therapeutic drug monitoring (TDM) protocols.
• Used in the development and validation of regulatory-compliant analytical methods for Good Laboratory Practice (GLP) and clinical trials.
• Facilitates research into the structure-activity relationship (SAR) of fluorinated and deuterated neuroleptic agents.

Basic Information

Product Name	5-Fluoro Paliperidone-D4
CAS No.	1346602-73-0
Molecular Formula	C23H23D4FN4O3
Molecular Weight	426.51 g/mol (for deuterated form)
Synonyms	9-Hydroxyrisperidone-d4 (5-Fluoro); 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one-d4; Paliperidone-d4 (5-Fluoro); 5-Fluoro Paliperidone (d4); Deuterated Paliperidone Internal Standard; 5-F-Paliperidone-d4; (RS)-9-Hydroxyrisperidone-d4; FLU-paliperidone-d4
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro Paliperidone-D4 is manufactured and analyzed under strict quality systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical documentation. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and identity confirmation (by NMR and IR) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.