Description

Rac n-Desmethyl-n-(4-Methoxyphenethyl) Venlafaxine-D3 is a deuterated isotopologue and a key synthetic intermediate of the active metabolite of Venlafaxine, a widely prescribed serotonin-norepinephrine reuptake inhibitor (SNRI). This compound is essential for pharmaceutical research and development, particularly in the synthesis of labeled metabolites for use in drug metabolism and pharmacokinetic (DMPK) studies. It serves as a critical reference standard and building block for analytical chemists and medicinal researchers in the pharmaceutical industry, enabling precise quantification and metabolic pathway elucidation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis of Venlafaxine and its metabolites in biological matrices via LC-MS/MS.
• Drug Metabolism Studies: Critical for conducting absorption, distribution, metabolism, and excretion (ADME) studies to trace metabolic pathways and identify metabolites.
• Isotopic Dilution Mass Spectrometry: Employed as an internal standard to enhance the accuracy and precision of mass spectrometric assays, compensating for matrix effects and instrument variability.
• Synthetic Intermediate: Serves as a key precursor in the organic synthesis of more complex, deuterated drug molecules for research purposes.
• Bioanalytical Method Development: Utilized in the development and validation of robust analytical methods for therapeutic drug monitoring (TDM) and clinical research.
• Pharmacokinetic Research: Aids in studying the bioavailability, half-life, and clearance rates of Venlafaxine in preclinical and clinical research settings.

Basic Information

Product Name	Rac n-Desmethyl-n-(4-Methoxyphenethyl) Venlafaxine-D3
CAS No.	1346602-72-9
Molecular Formula	C19H22D3NO2
Molecular Weight	306.43 g/mol
Synonyms	O-Desmethylvenlafaxine D3; ODV D3; Desvenlafaxine D3 (deuterated); rac-N-Desmethyl-N-(4-methoxyphenethyl)venlafaxine-d3; 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol-d3; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol D3 methyl ether; Venlafaxine metabolite D3
EINECS	Contact for details

Quality Control

Our Rac n-Desmethyl-n-(4-Methoxyphenethyl) Venlafaxine-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and determination of isotopic enrichment. We provide comprehensive Certificates of Analysis (COA) that detail all specifications and test results, ensuring traceability and compliance with research-grade material standards. Custom synthesis and purification to meet specific client purity requirements (e.g., >98%, >99%) are available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require desiccant. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.