Description

Rac-3-Aminoisobutyric Acid-D3 Hydrochloride is a deuterium-labeled isotopologue of the non-proteinogenic amino acid 3-aminoisobutyric acid, supplied as a stable hydrochloride salt. This compound serves as a critical internal standard and metabolic tracer in advanced analytical and biomedical research, enabling precise quantification and pathway analysis. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on metabolomics, pharmacokinetics, and stable isotope labeling studies.

Application

• Internal Standard for LC-MS/MS and GC-MS Analysis: Essential for the accurate quantification of endogenous 3-aminoisobutyric acid and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Metabolic Pathway Tracing: Used in stable isotope-resolved metabolomics (SIRM) to investigate the catabolism of thymine and valine, providing insights into inborn errors of metabolism and cancer metabolism.
• Biomarker Research and Assay Development: Facilitates the development and validation of high-sensitivity diagnostic assays for metabolic disorders such as hyper-β-aminoisobutyric aciduria (BAIB).
• Pharmaceutical Drug Metabolism and Pharmacokinetics (DMPK): Employed as a tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of novel therapeutic compounds.
• Synthesis of Labeled Compounds: Acts as a deuterated building block for the synthesis of more complex isotopically labeled peptides, prodrugs, or chemical probes.
• Quality Control Reference Material: Serves as a certified reference material (CRM) for ensuring the accuracy and precision of analytical methods in quality control laboratories.

Basic Information

Item	Details
Product Name	Rac-3-Aminoisobutyric Acid-D3 Hydrochloride
CAS No.	1346602-62-7
Molecular Formula	C4H5D3ClNO2
Molecular Weight	138.58 g/mol (for monoisotopic mass)
Synonyms	3-Amino-2-methylpropionic Acid-d3 Hydrochloride; (±)-3-Aminoisobutyric Acid-d3 HCl; DL-3-Aminoisobutyric Acid-d3 Hydrochloride; β-Aminoisobutyric Acid-d3 HCl; BAIB-d3 Hydrochloride; 3-Amino-2-methylpropanoic Acid-d3 Hydrochloride; (RS)-3-Amino-2-methylpropionic Acid-d3 Hydrochloride; 2-Methyl-β-alanine-d3 Hydrochloride
EINECS	Contact for details

Quality Control

Our Rac-3-Aminoisobutyric Acid-D3 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical and isotopic purity, NMR for structural confirmation, and mass spectrometry for isotopic enrichment verification. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.