Description

(6S)-2-N,6-n-Bis(1,1-Dideuteriopropyl)-4,5,6,7-Tetrahydro-1,3-Benzothiazole-2,6-Diamine is a deuterated derivative of a tetrahydrobenzothiazole diamine, a sophisticated chemical building block designed for advanced research and development. This compound matters for its role as a stable isotope-labeled internal standard in quantitative mass spectrometry, enabling precise pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D teams, analytical laboratories, and contract research organizations (CROs) focused on developing and validating novel therapeutic agents.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled reference compound for the accurate quantification of its non-deuterated counterpart in biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates studies on absorption, distribution, metabolism, and excretion (ADME) of lead pharmaceutical compounds.
• Bioanalytical Method Development: Critical for developing and validating robust, high-sensitivity analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Metabolite Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.
• Preclinical and Clinical Research: Supports toxicology studies and clinical trials by providing reliable data on drug exposure and clearance.
• Chemical Biology Probes: Can be utilized to create labeled probes for studying specific biochemical pathways and target engagement.

Basic Information

Product Name	(6S)-2-N,6-n-Bis(1,1-Dideuteriopropyl)-4,5,6,7-Tetrahydro-1,3-Benzothiazole-2,6-Diamine
CAS No.	1346602-54-7
Molecular Formula	C16H24D4N4S
Molecular Weight	308.51 g/mol
Synonyms	(6S)-2,6-Diamino-2,6-bis(1,1-dideuteriopropyl)-4,5,6,7-tetrahydro-1,3-benzothiazole; (6S)-2,6-Bis(1,1-dideuteriopropyl)-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; Deuterated Tetrahydrobenzothiazole Diamine; d4-(6S)-2-N,6-n-Bis(propyl)-4,5,6,7-Tetrahydro-1,3-Benzothiazole-2,6-Diamine; Stable Isotope-Labeled Benzothiazole; (6S)-2,6-Diamino-2,6-di(propyl-d7)-4,5,6,7-tetrahydrobenzothiazole (common naming variant); Benzothiazole-2,6-diamine, 4,5,6,7-tetrahydro-2,6-bis(1,1-dideuteriopropyl)-, (6S)-
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (typically >98 atom % D), chemical purity, and confirming identity and structure. We support compliance with cGMP and ISO 9001 standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.