Description

n-[2,3,5,6-Tetradeuterio-4-(4-Nitrophenyl)Sulfonylphenyl]Acetamide CAS NO 1346602-08-1 is a deuterated derivative of a key sulfonamide intermediate, offering enhanced stability and unique metabolic properties for advanced research applications. This high-purity compound is critical for pharmaceutical development, particularly in the creation of stable isotope-labeled internal standards for mass spectrometry. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, metabolism studies, and analytical method development.

Application

• As a stable isotope-labeled internal standard for the precise quantification of parent compounds in bioanalytical methods using LC-MS/MS.
• In pharmaceutical research and development for tracing metabolic pathways and studying drug pharmacokinetics (PK) and pharmacodynamics (PD).
• For the synthesis of deuterated drug candidates where the incorporation of deuterium aims to improve metabolic stability and alter pharmacokinetic profiles.
• As a critical advanced intermediate in the synthesis of complex, labeled molecules for use in clinical trials and regulatory submissions.
• In academic research focused on reaction mechanisms and isotope effects in organic and medicinal chemistry.

Basic Information

Product Name	n-[2,3,5,6-Tetradeuterio-4-(4-Nitrophenyl)Sulfonylphenyl]Acetamide
CAS No.	1346602-08-1
Molecular Formula	C14H9D4N2O5S
Molecular Weight	333.35 g/mol
Synonyms	Deuterated N-[4-[(4-Nitrophenyl)sulfonyl]phenyl]acetamide; 4'-Acetamido-4-nitrobenzenesulfonanilide-d4; N-(4-((4-Nitrophenyl)sulfonyl)phenyl)acetamide-d4; Acetamide, N-[2,3,5,6-tetradeuterio-4-[(4-nitrophenyl)sulfonyl]phenyl]-; 4-Acetamidophenyl 4-nitrophenyl sulfone-d4; Stable Isotope Labeled Sulfonamide Intermediate; [D4]-Labeled N-Acetyl Sulfaphenazole Related Compound
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure exceptional isotopic and chemical purity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C), High-Resolution Mass Spectrometry (HRMS), and HPLC to confirm deuteration level and chemical identity. Certificates of Analysis (COA) are provided, detailing assay, isotopic enrichment (typically >98 atom % D), and impurity profiles, ensuring reliability for sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.