Description

9B-(4-Chlorophenyl)-1,2,3,9B-Tetrahydro-5H-Imidazo[2,1-A]Isoindol-5-One-D4 is a deuterated isotopologue of a key pharmaceutical intermediate, where specific hydrogen atoms are replaced with deuterium, offering enhanced metabolic stability for research and development. This compound is critical for advancing drug discovery programs, particularly in the creation of deuterated drug candidates with improved pharmacokinetic profiles. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and advanced material scientists focused on isotopic labeling and tracer studies. The compound, identified by CAS No. 1346601-41-9, is supplied to meet the stringent requirements of modern medicinal chemistry.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial building block for the development of deuterium-labeled drug molecules with potentially superior efficacy and safety profiles.
• Metabolic Stability Studies: Used as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) for accurate quantification and metabolic pathway analysis in biological matrices.
• Pharmacokinetics (PK) and Drug Metabolism (DMPK) Research: Enables precise tracking of a compound's absorption, distribution, metabolism, and excretion (ADME) in preclinical studies.
• Isotopic Tracer Applications: Facilitates mechanistic studies in chemical and biochemical reactions where tracking specific atoms is required.
• Reference Standard for Analytical Methods: Provides a high-purity standard for the development and validation of analytical methods (HPLC, GC-MS) for both labeled and unlabeled compounds.
• Advanced Material Research: Investigated for potential use in organic electronics and optoelectronics due to its fused heterocyclic structure.

Basic Information

Product Name	9B-(4-Chlorophenyl)-1,2,3,9B-Tetrahydro-5H-Imidazo[2,1-A]Isoindol-5-One-D4
CAS No.	1346601-41-9
Molecular Formula	C16H9D4ClN2O
Molecular Weight	288.78 g/mol
Synonyms	1,2,3,9B-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-one, 9B-(4-chlorophenyl)-, D4; Deuterated 9B-(4-Chlorophenyl)imidazoisoindolone; 9-(4-Chlorophenyl)-1,2,3,9-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one-d4; (9bR)-9b-(4-Chlorophenyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one-d4; Isotopically Labeled Imidazoisoindolone Derivative; 9B-(p-Chlorophenyl)-1,2,3,9B-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one-d4
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Quality Control

Our deuterated chemicals are produced and controlled under a strict quality management system. Each batch of 9B-(4-Chlorophenyl)-1,2,3,9B-Tetrahydro-5H-Imidazo[2,1-A]Isoindol-5-One-D4 undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, and ²H where applicable) and High-Performance Liquid Chromatography (HPLC) to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We support compliance with ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and deuterium labeling pattern
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR/LC-MS)	≥ 98 atom % D (at labeled positions)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.