Description

3-Indoxyl Sulfate-D4 Potassium Salt is a high-purity, isotopically labeled internal standard critical for advanced analytical quantification. This deuterated compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses by correcting for matrix effects and instrument variability. It is primarily required by research and diagnostic laboratories in the fields of metabolomics, biomedical research, and clinical chemistry for the precise measurement of indoxyl sulfate, a key uremic toxin.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard for the accurate quantification of endogenous indoxyl sulfate in complex biological matrices like plasma, serum, and urine.
• Biomedical & Metabolomics Research: Enables precise tracking and measurement of indoxyl sulfate pathways in studies related to chronic kidney disease (CKD), cardiovascular health, and gut microbiome metabolism.
• Clinical Diagnostics Development: Used in the development and validation of high-precision clinical assays for monitoring uremic toxin levels in patients.
• Pharmacokinetic & Drug Metabolism Studies: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) research to study compounds that affect or are affected by the indoxyl sulfate metabolic pathway.
• Quality Control in Reference Material Production: Acts as a critical component in manufacturing certified reference materials (CRMs) and quality control samples for diagnostic kits.

Basic Information

Product Name	3-Indoxyl Sulfate-D4 Potassium Salt
CAS No.	1346601-03-3
Molecular Formula	C8D4H3KO4S
Molecular Weight	251.31 g/mol (for deuterated form)
Synonyms	Indoxyl Sulfate-d4 Potassium Salt; Potassium 3-Indoxyl Sulfate-d4; Indican-d4 Potassium Salt; 1H-Indol-3-yl Sulfate-d4 Potassium Salt; IS-d4 (Internal Standard); 3-Indoxylyl Sulfate-d4 Potassium; Uremic Toxin Internal Standard-d4; Isotopically Labeled Indoxyl Sulfate Potassium Salt
EINECS	Contact for details

Quality Control

Every batch of 3-Indoxyl Sulfate-D4 Potassium Salt is manufactured under strict quality management systems. It undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm isotopic purity (≥98% D), chemical purity (≥95%), and the absence of interfering impurities. A detailed Certificate of Analysis (COA) providing lot-specific data is supplied with each shipment to ensure traceability and compliance with your research or diagnostic protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, it is recommended to keep the container sealed under vacuum or nitrogen. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in Water, DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.