Description

2-[[2-(4-Amino-3,5-Dichlorophenyl)-2-Hydroxyethyl]Amino]-3,3,3-Trideuterio-2-(Trideuteriomethyl)Propan-1-Ol CAS NO 1346601-00-0 is a deuterated derivative of a β-adrenergic receptor ligand, specifically designed for advanced research and development applications. This compound is critical for metabolic and pharmacokinetic studies, where its deuterium labeling provides a stable, non-radioactive isotopic tracer. It is primarily utilized by pharmaceutical R&D laboratories and contract research organizations (CROs) specializing in drug discovery and development.

Application

• Isotopic Tracer in Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track the absorption, distribution, metabolism, and excretion (ADME) of the parent compound in biological systems.
• Internal Standard for Quantitative Bioanalysis: Essential in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the accurate quantification of the non-deuterated drug in complex biological matrices like plasma and tissue.
• Mechanistic Research in Pharmacology: Employed to investigate the binding mechanisms and pathways of β-adrenergic receptor ligands without interfering with the compound's biological activity.
• Reference Standard for Analytical Method Development: Serves as a high-purity certified reference material (CRM) for validating analytical methods in quality control laboratories.
• Precursor in Synthesis of Labeled Metabolites: Used in the synthesis of further deuterated or tritiated metabolites for comprehensive safety and efficacy profiling.

Basic Information

Product Name	2-[[2-(4-Amino-3,5-Dichlorophenyl)-2-Hydroxyethyl]Amino]-3,3,3-Trideuterio-2-(Trideuteriomethyl)Propan-1-Ol
CAS No.	1346601-00-0
Molecular Formula	C₁₂H₁₀D₆Cl₂N₂O₂
Molecular Weight	309.23 g/mol (approx.)
Synonyms	Deuterated Salmeterol-d6; Salmeterol-d6; (RS)-Salmeterol-d6; 2-(Hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol-d6; 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol-d6; 2-[[2-(4-Amino-3,5-dichlorophenyl)-2-hydroxyethyl]amino]-3,3,3-trideuterio-2-(trideuteriomethyl)propan-1-ol; N-[2-Hydroxy-5-[1-hydroxy-2-[[1-[4-(4-methoxyphenyl)butyl]-4-piperidyl]amino]ethyl]phenyl]formamide-d6 (related analog); GSK-961081-d6 (potential research code)
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, ²H) and High-Resolution Mass Spectrometry (HRMS), to confirm isotopic enrichment and chemical purity. Certificates of Analysis (COA) are provided, detailing assay (by HPLC), deuterium content, and impurity profiles, ensuring compliance with research-grade standards. Stability data is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (²H NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.