Description

(±)-Methocarbamol-D3 (Methoxy-D3) is a deuterated analog of the centrally-acting muscle relaxant methocarbamol, specifically labeled on the methoxy group. This compound is a critical analytical standard and reference material used for precise quantification and metabolic studies in pharmaceutical research and development. It is essential for scientists and quality control laboratories in the pharmaceutical, contract research organization (CRO), and analytical chemistry sectors who require high-purity, isotopically labeled materials for method development, validation, and bioanalytical applications.

Application

• Internal Standard for LC-MS/MS: Serves as a stable isotope-labeled internal standard for the accurate quantification of methocarbamol in complex biological matrices (e.g., plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic and Metabolism Studies: Enables detailed investigation of the absorption, distribution, metabolism, and excretion (ADME) profile of methocarbamol in preclinical and clinical research.
• Bioanalytical Method Development & Validation: A key component in developing and validating robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Drug Impurity Profiling and Degradation Studies: Used as a reference marker in stability-indicating assays to identify and quantify potential degradants or process-related impurities.
• Forensic and Toxicology Analysis: Supports accurate detection and confirmation of methocarbamol in forensic toxicology screenings and compliance testing.
• Pharmaceutical Quality Control (QC): Employed in in-house QC laboratories to ensure the accuracy and precision of assay methods for drug substance and product testing.

Basic Information

Item	Details
Product Name	(±)-Methocarbamol-D3 (Methoxy-D3)
CAS No.	1346600-86-9
Molecular Formula	C11H12D3NO5
Molecular Weight	244.26 g/mol (approx.)
Synonyms	Methocarbamol (methoxy-D3); 3-(2-Methoxyphenoxy)-1,2-propanediol 1-carbamate (methoxy-D3); Guaifenesin carbamate-D3; Robaxin-D3; AHR-85-D3; 2-Hydroxy-3-(2-methoxyphenoxy)propyl carbamate (methoxy-D3); Carbamic acid, (2-hydroxy-3-(2-(methoxy-d3)phenoxy)propyl)-, (±)-; Deuterated Methocarbamol
EINECS	Contact for details

Quality Control

Every batch of (±)-Methocarbamol-D3 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. The product is characterized by NMR (1H, 13C), mass spectrometry, and HPLC to confirm chemical structure, isotopic purity (D-enrichment), and chemical purity. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting batch-specific results for identity, assay, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation upon absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.