Description

Gabapentin-D6 is a stable isotope-labeled analog of the pharmaceutical compound Gabapentin, where six hydrogen atoms are replaced by deuterium. This high-purity reference standard is essential for ensuring the accuracy and reliability of quantitative analytical methods, particularly in regulated environments. It is a critical material for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require definitive internal standards for mass spectrometry and NMR spectroscopy.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in bioanalytical method development and validation for pharmacokinetic studies.
• Pharmaceutical Impurity Profiling: Used in method development to identify and quantify potential impurities and degradation products in Gabapentin drug substances and finished products.
• Metabolite Tracing & Research: Enables precise tracking of Gabapentin and its metabolites in biological matrices for advanced pharmacological and toxicological research.
• Forensic Analysis: Provides a definitive reference for the accurate quantification of Gabapentin in forensic toxicology casework.
• Quality Control & Assurance: Serves as a certified reference material (CRM) for in-house method calibration and ensuring compliance with GLP and GMP guidelines.
• Clinical Diagnostics: Used in developing and validating assays for therapeutic drug monitoring (TDM) of Gabapentin in patient samples.

Basic Information

Product Name	Gabapentin-D6
CAS No.	1346600-67-6
Molecular Formula	C9H11D6NO2
Molecular Weight	177.26 g/mol
Synonyms	1-(Aminomethyl)cyclohexaneacetic-2,2,3,3,4,4-d6 acid; Gabapentin (hexadeuterated); Gabapentin-d6; [2H6]-Gabapentin; (1-Aminomethyl-1-cyclohexyl)acetic-d6 acid; GPB-d6; CI-945-d6; Neurontin-d6 (labeled analog)
EINECS	Contact for details

Quality Control

Our Gabapentin-D6 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (D-enrichment), chemical purity (by HPLC), residual solvents, and other critical parameters. We adhere to standards suitable for pharmaceutical reference materials, and custom synthesis to meet specific pharmacopeial (e.g., USP) or customer specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.