Description

4-Aminobenzamidine-D4 Dihydrochloride is a deuterated isotopologue of a potent and selective serine protease inhibitor. This compound is essential for research requiring high specificity and minimal background interference in proteomic and biochemical studies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic kit manufacturers for developing enzyme assays, mechanistic studies, and as an internal standard in quantitative mass spectrometry.

Application

• Internal standard for the quantitative analysis of benzamidine-based protease inhibitors using LC-MS/MS.
• Biochemical research tool for studying the kinetics and inhibition mechanisms of serine proteases like trypsin, thrombin, and plasmin.
• Critical reagent in proteomics for affinity purification and activity-based protein profiling (ABPP).
• Development of diagnostic assays and kits for clinical research targeting protease activity.
• Use in structural biology (e.g., X-ray crystallography) to study enzyme-inhibitor complexes.
• Pharmaceutical development for validating drug targets and screening novel therapeutic compounds.

Basic Information

Product Name	4-Aminobenzamidine-D4 Dihydrochloride
CAS No.	1346600-28-9
Molecular Formula	C7H6D4N4·2HCl
Molecular Weight	247.13 g/mol (for C7H6D4N4·2HCl)
Synonyms	p-Aminobenzamidine-D4 dihydrochloride; Benzamidine-2,3,5,6-d4, 4-amino-, dihydrochloride; 4-Amino-D4-benzamidine dihydrochloride; Deuterated Benzamidine Inhibitor; (4-Aminophenyl)(imino)methanaminium-2,3,5,6-d4 dichloride
EINECS	Contact for details

Quality Control

Our 4-Aminobenzamidine-D4 Dihydrochloride is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic purity and chemical identity, ensuring consistency for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.