Description

1-(Methyl-D3)-2-Imidazolidinone CAS NO 1346599-87-8 is a deuterated analog of 1-Methyl-2-imidazolidinone, where three hydrogen atoms on the methyl group are replaced by deuterium. This isotopic labeling is critical for creating internal standards in analytical chemistry, enabling precise quantification and metabolic pathway tracing. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries who require high-fidelity deuterated compounds for mass spectrometry, NMR spectroscopy, and advanced material science.

Application

• Internal Standard for LC-MS/MS: Used as a stable, isotopically labeled internal standard for the accurate quantification of 1-Methyl-2-imidazolidinone and related compounds in bioanalytical and environmental testing.
• Metabolic Studies & Pharmacokinetics: Employed as a tracer in drug metabolism and pharmacokinetic (DMPK) research to study the absorption, distribution, metabolism, and excretion of pharmaceutical agents.
• NMR Spectroscopy Solvent & Reagent: Serves as a deuterated solvent or reagent in nuclear magnetic resonance (NMR) spectroscopy to avoid signal interference from protons.
• Pharmaceutical Intermediate: Acts as a key deuterated synthon in the development of novel active pharmaceutical ingredients (APIs) where deuterium incorporation can enhance metabolic stability.
• Agrochemical Research: Utilized in the synthesis of deuterated agrochemicals for studying environmental fate, degradation pathways, and residue analysis.
• Material Science: Applied in the development of specialty polymers and advanced materials where deuterium labeling aids in structural analysis and property modulation.

Basic Information

Product Name	1-(Methyl-D3)-2-Imidazolidinone
CAS No.	1346599-87-8
Molecular Formula	C4H4D3N2O
Molecular Weight	103.13 g/mol
Synonyms	1-(Trideuteriomethyl)imidazolidin-2-one; 1-Methyl-d3-2-imidazolidinone; N-(Methyl-d3)-2-imidazolidinone; Deuterated 1-Methyl-2-imidazolidinone; 1-(Methyl-d3)-2-imidazolidinone; N-Methyl-d3-ethyleneurea; 1,3-Diazinan-2-one, 1-(methyl-d3)-; 1-(Trideuteromethyl)imidazolidin-2-one
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced under strict quality control protocols to ensure isotopic purity and chemical integrity. Each batch of 1-(Methyl-D3)-2-Imidazolidinone is characterized by advanced analytical techniques including NMR, HPLC, and Mass Spectrometry to confirm deuterium incorporation and chemical purity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic enrichment, and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong acids and bases. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.