Description

Ternidazole-D6 Hydrochloride CAS NO 1346599-62-9 is a deuterium-labeled isotopologue of the nitroimidazole antibiotic Ternidazole, where six hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical methods. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities for pharmacokinetic studies, drug metabolism research, and bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Ternidazole and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track the parent drug and its biotransformation pathways.
• Bioanalytical Method Development: Serves as a stable, non-interfering reference to establish and validate robust HPLC and UPLC methods compliant with FDA and ICH guidelines.
• Clinical Trial Support: Enables accurate measurement of drug concentration in patient samples during Phase I-IV clinical trials for anti-infective therapies.
• Forensic and Anti-Doping Analysis: Provides a definitive reference standard for confirmatory testing in forensic toxicology and sports anti-doping controls.
• Pharmaceutical Quality Control: Supports impurity profiling and stability-indicating assays for Ternidazole-based drug products.

Basic Information

Product Name	Ternidazole-D6 Hydrochloride
CAS No.	1346599-62-9
Molecular Formula	C8H5D6ClN3O3S
Molecular Weight	279.76 g/mol
Synonyms	1-[2-(Ethyl-d5-sulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole Hydrochloride; Ternidazole-d6 HCl; Deuterated Ternidazole Hydrochloride; Ternidazole (ethyl-d5) Hydrochloride; 2-Methyl-1-[2-[(1,1,2,2,2-pentadeuterioethyl)sulfonyl]ethyl]-5-nitro-1H-imidazole Hydrochloride
EINECS	Contact for details

Quality Control

Our Ternidazole-D6 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C) and Mass Spectrometry for structural confirmation and isotopic purity, and HPLC for chemical purity assessment. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on assay, isotopic enrichment, and related substances. Our quality commitment aligns with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.