Description

Chaetomellic Acid A Anhydride-D3 is a deuterated analog of a potent and selective farnesyltransferase inhibitor. This isotopically labeled compound is essential for advanced analytical and metabolic research, providing a critical internal standard for precise quantification. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic laboratories engaged in drug discovery, particularly in the study of protein prenylation pathways and cancer therapeutics.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial, non-interfering reference compound for the accurate quantification of Chaetomellic Acid A Anhydride in complex biological matrices.
• Metabolic Pathway Tracing: Used in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies to track the fate of the parent compound.
• Biochemical Research: A key tool for investigating the mechanism of action of farnesyltransferase inhibition in cellular and enzymatic assays.
• Drug Discovery & Development: Supports lead optimization and candidate validation stages in oncology and other therapeutic areas targeting Ras-related signaling.
• Stable Isotope Labeling: Enables precise and sensitive detection methods that are compliant with rigorous regulatory bioanalytical method requirements.

Basic Information

Product Name	Chaetomellic Acid A Anhydride-D3
CAS No.	1346599-49-2
Molecular Formula	C23H29D3O4
Molecular Weight	375.52 g/mol (for D3 isotopologue)
Synonyms	Deuterated Chaetomellic Acid A Anhydride; (2E,6E,10E)-13-[(Carboxy-2H3)methyl]-2,6,10-trimethyl-1-oxacyclotrideca-2,6,10-trien-4,8,12-trione; Farnesyltransferase Inhibitor D3; 13-(Tricarboxy-2H3methyl)-2,6,10-trimethyl-1-oxacyclotrideca-2,6,10-trien-4,8,12-trione; Isotope Labeled FTase Inhibitor; CAAD-D3
EINECS	Contact for details

Quality Control

Every batch of Chaetomellic Acid A Anhydride-D3 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and isotopic enrichment. Our quality commitment includes rigorous HPLC, NMR, and mass spectrometry analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming batch-specific data for chemical purity, isotopic purity (D-enrichment %), and solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum confirms molecular ion
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.