Description

3-[1-Hydroxy-2-(1,1,2,2,2-Pentadeuterioethylamino)Ethyl]Phenol:Hydrochloride is a deuterated derivative of a key pharmaceutical intermediate, offering enhanced stability and metabolic profiling for advanced research and development. This high-purity compound is critical for applications requiring precise isotopic labeling, such as in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug discovery and development, particularly for deuterium-based drug design and analytical method development.

Application

• Deuterated Pharmaceutical Intermediate: Serves as a stable, isotopically labeled building block for the synthesis of novel drug candidates with potentially improved metabolic profiles.
• Internal Standard for Mass Spectrometry: Used as a quantitative internal standard in LC-MS and GC-MS analyses for accurate bioanalytical method development and validation.
• Metabolic Pathway Tracing: Enables detailed studies of drug metabolism and disposition (DMPK) due to its deuterium labeling, allowing researchers to track compounds in biological systems.
• Reference Standard: Acts as a certified reference material (CRM) for quality control and regulatory submissions in pharmaceutical manufacturing.
• Research Chemical: Employed in academic and industrial research exploring the effects of deuterium incorporation on receptor binding, efficacy, and toxicity.

Basic Information

Product Name	3-[1-Hydroxy-2-(1,1,2,2,2-Pentadeuterioethylamino)Ethyl]Phenol:Hydrochloride
CAS No.	1346599-41-4
Molecular Formula	C10H11D5ClNO2 • (HCl)
Molecular Weight	Contact for details
Synonyms	Deuterated Phenylephrine Hydrochloride-d5; (R)-3-[1-Hydroxy-2-[(1,1,2,2,2-pentadeuterioethyl)amino]ethyl]phenol hydrochloride; Phenylephrine-d5 HCl; 3-Hydroxy-α-[(methylamino-d5)methyl]benzyl alcohol hydrochloride; m-Hydroxy-α-[(methylamino-d5)methyl]benzyl alcohol hydrochloride; L-Phenylephrine-d5 hydrochloride; (-)-m-Synephrine-d5 hydrochloride
EINECS	Contact for details

Quality Control

Our 3-[1-Hydroxy-2-(1,1,2,2,2-Pentadeuterioethylamino)Ethyl]Phenol:Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Mass Spectrometry, to confirm chemical identity, isotopic purity (deuterium enrichment), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.