Description

2-(Acetylamino)-1,2,3,4-Tetrahydro-5,8-Dimethoxy-2-Naphthalenecarboxylic Acid-13C is a stable isotope-labeled (13C) derivative of a complex naphthalene-based carboxylic acid, serving as a critical internal standard and tracer in advanced analytical research. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery and development.

Application

• Quantitative Bioanalysis: Used as an internal standard in LC-MS/MS and GC-MS methods for the precise quantification of the parent compound or its metabolites in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed as a stable isotope tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical candidates.
• Metabolomics Research: Facilitates the accurate identification and measurement of specific metabolic pathways in complex biological systems.
• Method Development and Validation: Critical for developing and validating robust, regulatory-compliant analytical methods in GLP and GMP environments.
• Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradation products during drug substance manufacturing.
• Clinical Research: Supports biomarker validation and therapeutic drug monitoring in clinical trial samples.

Basic Information

Item	Details
Product Name	2-(Acetylamino)-1,2,3,4-Tetrahydro-5,8-Dimethoxy-2-Naphthalenecarboxylic Acid-13C
CAS No.	1346599-12-9
Molecular Formula	C15H19NO5 (13C1)
Molecular Weight	Contact for details
Synonyms	2-Acetamido-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthoic Acid-13C; 2-(Acetylamino)-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthalenecarboxylic Acid-13C; 13C-Labeled 2-Acetamido-5,8-dimethoxytetralin-2-carboxylic Acid; 13C Isotopologue of AATDN; [13C]-2-Acetylamino-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthoic Acid; Stable Isotope Labeled Tetralin Derivative; Carbon-13 Labeled Naphthalenecarboxylic Acid Amide
EINECS	Contact for details

Quality Control

Our 2-(Acetylamino)-1,2,3,4-Tetrahydro-5,8-Dimethoxy-2-Naphthalenecarboxylic Acid-13C is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch undergoes rigorous testing, including HPLC for chemical purity, NMR and MS for structural confirmation and isotopic enrichment, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.