Description

1,4-Bis[3,4-Dihydro-2(1H)-Quinolinon-7-Oxy]Butane-D8 is a deuterated derivative of a bis-quinolinone compound, serving as a high-value stable isotope-labeled standard. This compound is critical for ensuring analytical accuracy and reliability in advanced research and development. It is primarily utilized by scientists and quality control professionals in the pharmaceutical, agrochemical, and analytical chemistry sectors for applications requiring precise quantification and metabolic studies.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for quantitative analysis in LC-MS/MS and GC-MS, providing superior accuracy in pharmacokinetic and bioanalytical studies.
• Metabolic Pathway Tracing: Used in drug metabolism and disposition (DMPK) studies to track and identify metabolites without interference from endogenous compounds.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredients (APIs).
• Environmental Fate Studies: Employed in agrochemical research to study the environmental degradation and transformation of chemical compounds.
• Biomedical Research: Facilitates proteomics and metabolomics research where precise isotopic labeling is required for pathway analysis.
• Quality Control & Method Development: Serves as a certified reference material for validating analytical methods and ensuring regulatory compliance in GLP/GMP environments.

Basic Information

Product Name	1,4-Bis[3,4-Dihydro-2(1H)-Quinolinon-7-Oxy]Butane-D8
CAS No.	1346599-01-6
Molecular Formula	C22H16D8N2O4
Molecular Weight	~376.45 g/mol (deuterated form)
Synonyms	1,4-Bis(7-hydroxy-3,4-dihydro-2(1H)-quinolinon-1-yl)butane-d8; Deuterated 1,4-Bis(7-oxy-3,4-dihydroquinolin-2(1H)-one)butane; 1,4-Bis(7-oxo-3,4-dihydro-2H-quinolin-1-yl)butane-d8; Bis-quinolinone-d8; Isotope-labeled quinolinone dimer; 1,4-Bis(7-hydroxy-1,2,3,4-tetrahydroquinolin-2-one)butane-d8; D8-1,4-BQOB; Stable Isotope-Labeled Standard (SILS) 1346599-01-6
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and Mass Spectrometry. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (e.g., D8, min. 98 atom % D), chemical purity, and relevant analytical data to support your research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D (D8)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.