Description

1-Acetyl-4-(2,4-Difluorobenzyl)Piperazine-D8 is a deuterated analog of a key pharmaceutical intermediate, where eight hydrogen atoms are replaced with deuterium, a stable isotope. This deuteration is critical for enhancing metabolic stability and for use as an internal standard in mass spectrometry, improving the accuracy and reliability of analytical data. This high-purity compound is essential for researchers and manufacturers in pharmaceutical development, metabolic studies, and analytical chemistry, particularly for pharmacokinetic and bioanalytical applications.

Application

• Deuterated Internal Standard for quantitative LC-MS/MS analysis in bioanalytical and pharmacokinetic studies.
• Metabolic Tracer in drug metabolism and disposition (DMPK) research to study metabolic pathways.
• Pharmaceutical Intermediate for the synthesis of deuterated drug candidates with improved pharmacokinetic profiles.
• Stable Isotope Labeling in chemical and biochemical research for mechanistic studies.
• Reference Material for method development and validation in analytical laboratories.
• Precursor for further chemical synthesis in medicinal chemistry programs.

Basic Information

Product Name	1-Acetyl-4-(2,4-Difluorobenzyl)Piperazine-D8
CAS No.	1346598-81-9
Molecular Formula	C₁₃H₈D₈F₂N₂O
Molecular Weight	~270.33 g/mol
Synonyms	1-[4-[(2,4-Difluorophenyl)methyl]piperazin-1-yl]ethanone-D8; N-Acetyl-4-(2,4-difluorobenzyl)piperazine-D8; 4-(2,4-Difluorobenzyl)-1-acetylpiperazine-D8; Deuterated 1-Acetyl-4-(2,4-difluorobenzyl)piperazine; Perdeuterated 1-Acetyl-4-(2,4-difluorobenzyl)piperazine; 1-Acetyl-4-(2,4-difluorobenzyl)piperazine (D8); 1-Acetyl-4-(2,4-difluorobenzyl)piperazine-d8; Acetyl-difluorobenzylpiperazine-D8
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control to ensure high isotopic purity and chemical integrity, meeting the exacting standards for research and development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-content), chemical purity, and identity confirmation. We adhere to cGMP principles where applicable to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.