Description

Diethyl 2-[4-(2,2-Dicarboethoxypropyl)Phenyl]-2-Methyl Malonate-D3 is a deuterated derivative of a key malonate ester intermediate, featuring a strategically placed deuterium isotope. This compound is specifically engineered for applications requiring enhanced metabolic stability and traceability in research and development. It is primarily utilized by pharmaceutical and agrochemical R&D teams engaged in the synthesis of novel active ingredients, where its isotopic label provides critical advantages in pharmacokinetic and mechanistic studies.

Application

• As a deuterium-labeled building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) for drug discovery and development.
• As a stable-isotope internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) for the accurate quantification of related compounds in biological matrices.
• In metabolism and pharmacokinetics (DMPK) studies to trace the metabolic fate of drug candidates and investigate isotope effects.
• For the research and development of deuterated agrochemicals, aiming to improve environmental persistence and efficacy.
• In advanced material science research for creating specialty polymers or organic electronic materials with modified properties.
• As a key synthetic intermediate in organic chemistry laboratories for method development and complex molecule construction.

Basic Information

Product Name	Diethyl 2-[4-(2,2-Dicarboethoxypropyl)Phenyl]-2-Methyl Malonate-D3
CAS No.	1346597-74-7
Molecular Formula	C22H29D3O8
Molecular Weight	427.48 g/mol (approx.)
Synonyms	Diethyl 2-[4-(2,2-Dicarboethoxypropyl)Phenyl]-2-Methyl Malonate-d3; 2-[4-(2,2-Dicarboethoxypropyl)Phenyl]-2-Methylmalonic Acid Diethyl Ester-d3; Diethyl 2-Methyl-2-[4-(2,2-diethoxycarbonylpropyl)phenyl]malonate-d3; Deuterated Diethyl 2-Methyl-2-(4-(2,2-di(ethoxycarbonyl)propyl)phenyl)malonate; 2-Methyl-2-[4-(2,2-diethoxycarbonylpropyl)phenyl]propanedioic Acid Diethyl Ester-d3; Diethyl 2-(4-(1,1-Bis(ethoxycarbonyl)propyl)phenyl)-2-methylmalonate-d3
EINECS	Contact for details

Quality Control

Every batch of our deuterated chemicals is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure isotopic purity, chemical purity, and structural integrity. Certificates of Analysis (COA) detailing specifications such as assay by HPLC, deuterium enrichment by NMR or MS, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.