Description

4,4-Difluorobut-3-En-1-Yl Chloride is a versatile fluorinated organic building block characterized by its reactive chloride and alkene functionalities. This compound is essential for introducing difluoroalkene motifs into complex molecular architectures, a key step in modulating the physical and biological properties of target molecules. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for constructing difluoroalkene bioisosteres in drug discovery, particularly for protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the difluoroalkene group enhances metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or cross-linking agent for synthesizing specialty polymers with unique surface properties and chemical resistance.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) to create complex fluorinated structures.
• Fluorine-Containing Fine Chemicals: A building block for producing specialty fluorinated compounds used in surfactants, coatings, and solvents.

Basic Information

Product Name	4,4-Difluorobut-3-En-1-Yl Chloride
CAS No.	1346521-43-4
Molecular Formula	C4H5ClF2
Molecular Weight	126.53 g/mol
Synonyms	4-Chloro-1,1-difluorobut-1-ene; 1-Chloro-4,4-difluorobut-3-ene; 4,4-Difluorobut-3-enyl chloride; (4,4-Difluorobut-3-en-1-yl)chloride; 3-Buten-1-yl, 4,4-difluoro-, chloride; But-3-ene-1-yl, 4,4-difluoro-, chloride; 4,4-Difluoro-3-buten-1-yl chloride
EINECS	Contact for details

Quality Control

Our 4,4-Difluorobut-3-En-1-Yl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its reactivity with strong bases and moisture-sensitive nature, keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.