Description

2-([(E)-(4-Chlorophenyl)Methylidene]Amino)-4,5,6,7-Tetrahydro-1-Benzothiophene-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its specific molecular architecture featuring a tetrahydrobenzothiophene core. This compound matters as a critical building block in modern organic synthesis, enabling the development of novel active pharmaceutical ingredients (APIs) with potential therapeutic applications. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, particularly for projects targeting central nervous system (CNS) disorders, inflammation, or oncology. The product, supplied under CAS NO 1346414-21-8, is essential for scientists requiring precise and reliable chemical scaffolds for drug discovery and process development.

Application

This specialized intermediate serves key roles in research and industrial synthesis:

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Heterocyclic Compound Synthesis: Exploited in constructing complex fused-ring systems common in many modern therapeutics.
• Ligand and Inhibitor Development: Serves as a core structure for designing enzyme inhibitors or receptor ligands in biochemical assays.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of target molecules.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists in both university laboratories and corporate R&D divisions.

Basic Information

Product Name	2-([(E)-(4-Chlorophenyl)Methylidene]Amino)-4,5,6,7-Tetrahydro-1-Benzothiophene-3-Carbonitrile
CAS No.	1346414-21-8
Molecular Formula	C16H13ClN2S
Molecular Weight	300.80 g/mol
Synonyms	2-[(E)-[(4-Chlorophenyl)methylene]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile; (E)-2-((4-Chlorobenzylidene)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile; 4,5,6,7-Tetrahydro-2-[[(4-chlorophenyl)methylene]amino]-1-benzothiophene-3-carbonitrile; 2-((4-Chlorobenzylidene)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile; 1346414-21-8; Benzothiophene-3-carbonitrile, 2-[[(4-chlorophenyl)methylene]amino]-4,5,6,7-tetrahydro-; A high-purity benzothiophene derivative intermediate.
EINECS	Contact for details

Quality Control

Our 2-([(E)-(4-Chlorophenyl)Methylidene]Amino)-4,5,6,7-Tetrahydro-1-Benzothiophene-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity (typically ≥95% to ≥98% by HPLC), physical characteristics, and impurity profiles are provided with every shipment. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 1.0 %
Residue on Ignition	≤ 0.5 %
Single Unknown Impurity (HPLC)	≤ 1.0 %
Total Impurities (HPLC)	≤ 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.