Description

(S)-Methyl 2-(2-Chlorophenyl)-2-(2-(Hydroxymethyl)-6,7- Dihydrothieno[3,2-C]Pyridin-5(4H)-Yl)Acetate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it serves as a critical building block for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise stereochemistry. Pharmaceutical research and development organizations, as well as advanced fine chemical manufacturers, need this material for the efficient and scalable production of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly those targeting neurological and cardiovascular disorders.
• API Development: Used in research and process development for new Active Pharmaceutical Ingredients (APIs) where the (S)-enantiomer configuration is crucial for biological activity.
• Preclinical & Clinical Trial Material Manufacturing: Sourced for producing batches of investigational compounds required for toxicology studies and clinical trials.
• Asymmetric Synthesis: Employed in advanced organic synthesis routes that leverage its defined stereocenter to construct more complex molecular architectures.
• Process Chemistry Optimization: Used by process chemists to develop and scale up efficient, cost-effective synthetic pathways for target molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-Methyl 2-(2-Chlorophenyl)-2-(2-(Hydroxymethyl)-6,7- Dihydrothieno[3,2-C]Pyridin-5(4H)-Yl)Acetate
CAS No.	1346231-35-3
Molecular Formula	C19H20ClNO3S
Molecular Weight	377.88 g/mol
Synonyms	(S)-Methyl 2-(2-Chlorophenyl)-2-((2-(hydroxymethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl))acetate; Methyl (2S)-2-(2-chlorophenyl)-2-[2-(hydroxymethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl]acetate; (S)-2-(2-Chlorophenyl)-2-(2-(hydroxymethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid methyl ester; UNII-9F4V8C1Q7F; 9F4V8C1Q7F; Ticagrelor Intermediate; AZD6140 Intermediate; Thienopyridine derivative intermediate.
EINECS	Contact for details

Quality Control

Our (S)-Methyl 2-(2-Chlorophenyl)-2-(2-(Hydroxymethyl)-6,7- Dihydrothieno[3,2-C]Pyridin-5(4H)-Yl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; the container should be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.