Description

4-Iodo-1,1,1-Trifluoro-2-(Trifluoromethyl)Butane is a specialized fluorinated and iodinated organic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both perfluoroalkyl and iodo functional groups, makes it a valuable precursor for introducing fluorinated segments into target molecules, which is critical for modifying physical and chemical properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as the synthesis of novel bioactive compounds and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated drug candidates, where the introduction of fluorine atoms can enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging the fluorine and iodine motifs to create compounds with specific biological activity and environmental persistence profiles.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers and coatings with unique surface properties, such as oil and water repellency (oleophobicity/hydrophobicity).
• Liquid Crystal & OLED Material Research: Employed in the synthesis of fluorinated components for electronic display and lighting technologies to improve performance and stability.
• Fluorinated Surfactant & Lubricant Development: Acts as an intermediate for creating high-performance surfactants and lubricants with exceptional thermal and chemical resistance.
• Cross-Coupling Reactions: The iodine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex fluorinated architectures.

Basic Information

Product Name	4-Iodo-1,1,1-Trifluoro-2-(Trifluoromethyl)Butane
CAS No.	1346176-00-8
Molecular Formula	C5H5F6I
Molecular Weight	306.00 g/mol
Synonyms	1,1,1-Trifluoro-4-iodo-2-(trifluoromethyl)butane; 4-Iodo-1,1,1-trifluoro-2-(trifluoromethyl)butane; 2-(Trifluoromethyl)-1,1,1-trifluoro-4-iodobutane; 4-Iodo-2-(trifluoromethyl)-1,1,1-trifluorobutane; Perfluoro-tert-butyl iodide derivative; (3-Iodopropyl)trifluoromethyl-difluoromethyl ketone (structural analog); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of 4-Iodo-1,1,1-Trifluoro-2-(Trifluoromethyl)Butane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and industrial applications. Each lot undergoes comprehensive analytical characterization, including NMR (1H, 13C, 19F), GC-MS, and HPLC analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to the presence of iodine and fluorinated alkyl groups, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability to prevent potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.