Description

9Alpha,11,15S-Trihydroxy-Thromba-5Z,13E-Dien-1-Oic-3,3,4,4-D4 Acid is a deuterated analog of a key thromboxane A2 metabolite, specifically designed for advanced research and analytical applications. This compound is critical for use as a high-purity internal standard in mass spectrometry, enabling precise quantification and metabolic pathway studies in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions focused on cardiovascular pharmacology, eicosanoid biology, and drug metabolism studies.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of thromboxane metabolites in plasma, urine, and tissue samples.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in stable isotope dilution assays to study the bioavailability and clearance of cardiovascular drugs.
• Biomarker Research: Facilitates the development and validation of sensitive assays for oxidative stress and inflammatory biomarkers.
• Synthetic Reference Material: Serves as a certified reference material for calibrating analytical instruments and ensuring method accuracy.
• Preclinical Studies: Employed in animal models to investigate the role of thromboxane in thrombosis, atherosclerosis, and inflammation.
• Quality Control in Pharma: Used in the quality control of drug substances and products targeting the arachidonic acid pathway.

Basic Information

Item	Detail
Product Name	9Alpha,11,15S-Trihydroxy-Thromba-5Z,13E-Dien-1-Oic-3,3,4,4-D4 Acid
CAS No.	1346112-79-5
Molecular Formula	C₂₀H₂₈D₄O₆
Molecular Weight	Contact for details
Synonyms	11-Dehydro-thromboxane B2-d4; 11-Dehydro-TXB2-d4; 11-Dehydrothromboxane B2-d4; 9α,11,15S-Trihydroxy-thromba-5Z,13E-dien-1-oic-3,3,4,4-d4 Acid; Deuterated 11-Dehydro-thromboxane B2; 11-Dehydro-TXB2 Deuterated Standard; TXB2 Metabolite-d4; [3,3,4,4-²H₄]-11-Dehydro-thromboxane B2
EINECS	Contact for details

Quality Control

Every batch of 9Alpha,11,15S-Trihydroxy-Thromba-5Z,13E-Dien-1-Oic-3,3,4,4-D4 Acid is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and deuterium enrichment. Our quality commitment ensures reliability for your most sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.