Description

(R)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylicacid is a high-purity chiral building block essential for advanced pharmaceutical synthesis. This compound matters as a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs, where its specific stereochemistry is critical for biological activity. Pharmaceutical research and development organizations, as well as fine chemical manufacturers, need this material for creating novel therapeutic agents and for process chemistry optimization.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in neurological and cardiovascular research.
• API Development: Used in the research and process development of Active Pharmaceutical Ingredients (APIs) requiring the tetrahydroisoquinoline scaffold.
• Asymmetric Synthesis: Serves as a starting material or intermediate in asymmetric synthesis routes due to its defined (R)-configuration.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs in drug discovery.
• Peptidomimetics: The carboxylic acid functionality allows for incorporation into peptide-like structures for creating peptidomimetic compounds.
• Chemical Biology Probes: Used in the development of chemical probes for studying biological pathways and target validation.

Basic Information

Item	Information
Product Name	(R)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylicacid
CAS No.	1344504-74-0
Molecular Formula	C10H10BrNO2
Molecular Weight	256.10 g/mol
Synonyms	(R)-5-Bromo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (3R)-5-Bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 5-Bromo-(R)-Tic-OH; (R)-5-Br-Tic-OH; 5-Bromo-D-Tic-OH; (R)-5-Bromo-tetrahydroisoquinoline-3-carboxylic acid; (R)-5-Bromo-TIQ-3-COOH
EINECS	Contact for details

Quality Control

Our (R)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylicacid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, chiral purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.