Description

(3S)-5-Methoxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its core value proposition lies in its stereochemically defined structure, which is critical for the development of enantiomerically pure active pharmaceutical ingredients (APIs) and bioactive molecules. This compound is essential for research and production in the pharmaceutical industry, particularly for medicinal chemists and process development scientists working on central nervous system (CNS) agents, alkaloid derivatives, and other therapeutic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing novel chemical libraries in drug discovery programs.
• Asymmetric Synthesis: Serves as a precursor for catalysts or ligands used in stereoselective chemical transformations.
• Alkaloid Analog Development: Employed in the research and synthesis of tetrahydroisoquinoline-based natural product analogs with potential biological activity.
• Process Chemistry & Scale-up: Utilized in the development and optimization of commercial-scale manufacturing routes for APIs.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(3S)-5-Methoxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	1344413-01-9
Molecular Formula	C11H13NO3
Molecular Weight	207.23 g/mol
Synonyms	(3S)-5-Methoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid; (S)-5-Methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 5-Methoxy-D-Tic-OH; (S)-5-Methoxy-Tic-OH; L-5-Methoxytetrahydroisoquinoline-3-carboxylic acid; (3S)-5-Methoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; 5-MeO-Tic; (S)-5-Methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our (3S)-5-Methoxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.