Description

(S)-6-Chloro-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity chiral building block of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with specific stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug discovery.
• Peptidomimetics & Constrained Peptide Synthesis: Used to introduce the rigid, chiral tetrahydroisoquinoline scaffold into peptide backbones to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Serves as a starting material or precursor for catalysts and ligands used in enantioselective transformations.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes and molecular tools for studying enzyme function and protein-protein interactions.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Sourced for the pilot and commercial-scale manufacturing of chiral APIs requiring this specific stereochemical framework.

Basic Information

Product Name	(S)-6-Chloro-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	1344407-69-7
Molecular Formula	C10H10ClNO2
Molecular Weight	211.65 g/mol
Synonyms	(3S)-6-Chloro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-6-Chloro-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (S)-6-Chloro-Tic-OH; (S)-6-Chloro-Tic; 6-Chloro-D-Tic; (S)-6-Chloro-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; (S)-6-Cl-Tic-OH
EINECS	Contact for details

Quality Control

Our (S)-6-Chloro-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identity and impurity profiling, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.