Description

5-Bromo-8-Fluoro-1,2,3,4-Tetrahydroisoquinoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is specifically engineered to serve as a critical precursor in the development of novel active pharmaceutical ingredients (APIs) and complex agrochemicals. It is primarily sought after by research institutions and industrial-scale manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of central nervous system (CNS) and oncology drug candidates, particularly those targeting specific receptor subtypes.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, leveraging the biological activity of the halogenated isoquinoline scaffold.
• Ligand & Catalyst Development: Serves as a precursor for creating novel nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into the synthesis of advanced organic electronic materials and photoactive compounds.
• Chemical Biology Probe: Utilized in medicinal chemistry to build molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring functionalized tetrahydroisoquinoline cores.

Basic Information

Product Name	5-Bromo-8-Fluoro-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1342747-87-8
Molecular Formula	C9H9BrFN
Molecular Weight	230.08 g/mol
Synonyms	5-Bromo-8-fluoro-1,2,3,4-tetrahydroisoquinoline; 8-Fluoro-5-bromo-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-5-bromo-8-fluoro-isoquinoline; 5-Bromo-8-fluoro-THIQ; 1342747-87-8; 5-Br-8-F-THIQ
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-8-Fluoro-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure batch-to-batch consistency and high purity. Our standard grade meets typical research and development requirements, with Certificates of Analysis (COA) provided for each shipment, detailing purity, identity, and impurity profiles. We adhere to cGMP principles for production intended for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.