Description

7-Bromo-5-Fluoro-3,4-Dihydroisoquinolin-1(2H)-One is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery. This compound serves as a critical building block for the synthesis of novel, biologically active molecules, particularly in the development of central nervous system (CNS) and oncology therapeutics. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the creation of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• API Synthesis: Incorporated into the final synthetic route for active pharmaceutical ingredients, particularly those with isoquinoline or dihydroisoquinoline scaffolds.
• CNS Drug Development: Serves as a building block for compounds being investigated for neurological and psychiatric disorders.
• Oncology Research: Utilized in the development of potential kinase inhibitors and other targeted cancer therapies.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis and scale-up projects under cGMP conditions.
• Academic Research: Employed in university and institutional labs for fundamental organic synthesis and heterocyclic chemistry studies.

Basic Information

Item	Information
Product Name	7-Bromo-5-Fluoro-3,4-Dihydroisoquinolin-1(2H)-One
CAS No.	1341674-79-0
Molecular Formula	C9H7BrFNO
Molecular Weight	244.06 g/mol
Synonyms	7-Bromo-5-fluoro-1,2,3,4-tetrahydroisoquinolin-1-one; 7-Bromo-5-fluoro-3,4-dihydro-1H-isoquinolin-1-one; 1(2H)-Isoquinolinone, 7-bromo-5-fluoro-3,4-dihydro-; 7-Br-5-F-DHIQ; 7-Bromo-5-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 7-Bromo-5-Fluoro-3,4-Dihydroisoquinolin-1(2H)-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects with material suitable for research use, pilot plant scale-up, and can supply under cGMP guidelines for advanced clinical stage manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.