Description

8-Bromo-5-Fluoro-1,2,3,4-Tetrahydroisoquinoline is a high-value, multi-functional heterocyclic building block essential for modern organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, particularly in the development of new active pharmaceutical ingredients (APIs). Pharmaceutical researchers, agrochemical developers, and advanced material scientists need this precise intermediate to create novel compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially for central nervous system (CNS) disorders, oncology, and cardiovascular diseases.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides by incorporating the halogenated tetrahydroisoquinoline core.
• Ligand Synthesis: Serves as a building block for creating complex ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design of molecular probes for studying enzyme function and biological pathways.
• Fluorinated Compound Libraries: A critical component for generating diverse compound libraries in medicinal chemistry for high-throughput screening.
• Advanced Material Development: Used in the research of organic electronic materials and liquid crystals due to its rigid, substituted aromatic structure.

Basic Information

Product Name	8-Bromo-5-Fluoro-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1341214-45-6
Molecular Formula	C9H9BrFN
Molecular Weight	230.08 g/mol
Synonyms	8-Bromo-5-fluoro-1,2,3,4-tetrahydroisoquinoline; 5-Fluoro-8-bromo-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-8-bromo-5-fluoro-isoquinoline; 8-Bromo-5-fluoro-3,4-dihydro-1H-isoquinoline; 1341214-45-6; 8-Br-5-F-THIQ
EINECS	Contact for details

Quality Control

Our 8-Bromo-5-Fluoro-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, NMR, and MS, to verify identity and purity. Certificates of Analysis (COA) are available for every batch and provided upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.