Description

2-Bromo-5-Difluoromethyl-[1,3,4]Thiadiazole is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique molecular architecture, featuring both bromine and difluoromethyl substituents on a thiadiazole core, makes it a critical intermediate for introducing specific functionalities into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing potential drug candidates, particularly in medicinal chemistry programs targeting new small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiadiazole ring.
• Material Science Research: Serves as a precursor for creating novel fluorinated heterocyclic compounds with potential applications in electronic materials or liquid crystals.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form carbon-carbon bonds.
• Fluorine Chemistry: The difluoromethyl group is a valuable isostere and can be used to modulate the lipophilicity, metabolic stability, and bioavailability of lead compounds.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Bromo-5-Difluoromethyl-[1,3,4]Thiadiazole
CAS No.	1340313-49-6
Molecular Formula	C3H2BrF2N2S
Molecular Weight	216.02 g/mol
Synonyms	2-Bromo-5-(difluoromethyl)-1,3,4-thiadiazole; 5-(Difluoromethyl)-2-bromo-1,3,4-thiadiazole; 1,3,4-Thiadiazole, 2-bromo-5-(difluoromethyl)-; 2-Bromo-5-difluoromethylthiadiazole; Br-DFMT; [1,3,4]Thiadiazole, 2-bromo-5-(difluoromethyl)-
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our advanced intermediates. Production of 2-Bromo-5-Difluoromethyl-[1,3,4]Thiadiazole is monitored through in-process controls and final release testing via modern analytical techniques including HPLC, GC, and NMR to ensure high chemical purity and lot-to-lot consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.