Description

6-Bromo-8-Fluoro-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate featuring a halogenated tetrahydroisoquinoline scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules. It is primarily sought after by pharmaceutical and biotechnology companies engaged in the synthesis of novel drug candidates, particularly in the areas of central nervous system (CNS) and oncology therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• CNS Drug Development: Employed in the research of potential therapeutics for neurological disorders, leveraging the privileged tetrahydroisoquinoline structure.
• Oncology Research: Serves as a building block for developing small-molecule inhibitors and targeted cancer therapies.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	6-Bromo-8-Fluoro-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1339780-81-2
Molecular Formula	C9H9BrFN
Molecular Weight	230.08 g/mol
Synonyms	6-Bromo-8-fluoro-1,2,3,4-tetrahydroisoquinoline; 8-Fluoro-6-bromo-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-6-bromo-8-fluoro-isoquinoline; 6-Bromo-8-fluoro-3,4-dihydro-1H-isoquinoline; 1339780-81-2; 6-Br-8-F-THIQ
EINECS	Contact for details

Quality Control

Our 6-Bromo-8-Fluoro-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.