Description

(R)-3-(tert-Butyl)-4-(2-Methoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is a high-value, chiral organophosphorus compound featuring a unique oxaphosphole heterocyclic structure. This compound is of significant interest as a sophisticated ligand precursor or chiral building block in advanced synthetic chemistry. It is primarily utilized by research and development teams in the pharmaceutical and fine chemical industries who require high-purity, specialized intermediates for asymmetric synthesis and catalyst development.

Application

• Asymmetric Catalysis: Serves as a precursor for chiral phosphine or phosphite ligands used in transition metal-catalyzed reactions like hydrogenation and cross-coupling.
• Pharmaceutical Intermediate: Acts as a key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological or metabolic diseases.
• Advanced Material Research: Investigated for incorporation into novel organic frameworks or polymers where the chiral phosphorus center imparts specific electronic or steric properties.
• Agrochemical Synthesis: Used in the research and development of chiral, biologically active molecules for crop protection agents.
• Methodology Development: Employed by academic and industrial research groups to develop new synthetic methodologies involving P-stereogenic compounds.

Basic Information

Product Name	(R)-3-(tert-Butyl)-4-(2-Methoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole
CAS No.	1338454-28-6
Molecular Formula	C19H23O2P
Molecular Weight	314.36 g/mol
Synonyms	(R)-3-tert-Butyl-4-(2-methoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; (R)-3-(tert-Butyl)-4-(o-methoxyphenyl)-2,3-dihydro-1,3-benzoxaphosphole; (R)-DTBM-SEGPHOS Oxide (structural analog); P-Chiral Oxaphosphole; (R)-3-(1,1-Dimethylethyl)-4-(2-methoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole
EINECS	Contact for details

Quality Control

Every batch of our (R)-3-(tert-Butyl)-4-(2-Methoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is synthesized and purified under controlled conditions to ensure exceptional chiral purity and chemical integrity. Our products undergo rigorous quality testing, including chiral HPLC and NMR analysis, to ensure compliance with stringent research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.