Description

tert-Butyl 5-Bromo-4-Fluoroindoline-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the indoline class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates, especially those targeting neurological disorders and cancer.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new therapeutic agents.
• API Synthesis: Serves as a crucial scaffold for constructing complex indoline-based active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Agrochemical Research: Potential application as an intermediate in the development of new agrochemicals due to its halogenated indoline structure.

Basic Information

Item	Detail
Product Name	tert-Butyl 5-Bromo-4-Fluoroindoline-1-Carboxylate
CAS No.	1337533-31-9
Molecular Formula	C13H15BrFNO2
Molecular Weight	316.17 g/mol
Synonyms	1-Boc-5-Bromo-4-fluoroindoline; 5-Bromo-4-fluoroindoline-1-carboxylic acid tert-butyl ester; tert-Butyl 5-bromo-4-fluoro-2,3-dihydro-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 5-bromo-4-fluoro-2,3-dihydro-, 1,1-dimethylethyl ester; Boc-5-Bromo-4-fluoroindoline; 5-Bromo-4-fluoro-N-Boc-indoline; 1337533-31-9
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Bromo-4-Fluoroindoline-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.