Description

(1E,4Z,6E)-5-Hydroxy-1,7-Bis[4-Hydroxy-3-(Methoxy-D3)Phenyl]-1,4,6-Heptatrien-3-One CAS NO 1335198-02-1 is a deuterated analog of curcumin, a polyphenolic compound of significant research interest. This compound is valued for its enhanced metabolic stability and utility as an internal standard in analytical chemistry, enabling precise quantification and pharmacokinetic studies. It is primarily required by pharmaceutical researchers, analytical laboratories, and manufacturers of high-purity reference standards for drug development and quality control.

Application

• Analytical Reference Standard: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and High-Performance Liquid Chromatography (HPLC) methods for the accurate quantification of curcumin and its metabolites.
• Pharmaceutical Research: Used in preclinical and clinical studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of curcuminoid-based therapeutics due to its isotopic label.
• Metabolite Tracing: Employed in stable isotope labeling experiments to trace metabolic pathways and identify biotransformation products in biological systems.
• Method Development & Validation: Essential for developing and validating robust bioanalytical assays in compliance with Good Laboratory Practice (GLP) and ICH guidelines.
• Nutraceutical Analysis: Used to ensure the quality, authenticity, and precise potency measurement in curcuminoid-containing dietary supplements and functional foods.
• Chemical Biology Probes: Acts as a molecular probe to study the binding interactions and mechanisms of action of curcuminoids with biological targets without interference from endogenous compounds.

Basic Information

Product Name	(1E,4Z,6E)-5-Hydroxy-1,7-Bis[4-Hydroxy-3-(Methoxy-D3)Phenyl]-1,4,6-Heptatrien-3-One
CAS No.	1335198-02-1
Molecular Formula	C21H16D6O6
Molecular Weight	376.43 g/mol
Synonyms	Curcumin-d6; Deuterated Curcumin (hexadeuterated); 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one-3,3',4,4',5,5'-d6; Curcumin (Methoxy-d3, 3,3',5,5'); Hexadeuterocurcumin; [Methoxy-d3]-Curcumin; Bisdesmethoxycurcumin-d6 analog; Internal Standard for Curcumin Analysis
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems. Each batch undergoes comprehensive analysis using techniques including NMR, HPLC, and MS to confirm isotopic purity (≥98 atom % D) and chemical purity (≥95% by HPLC). Certificates of Analysis (COA) are provided, detailing batch-specific results for identity, purity, and isotopic enrichment, supporting research reproducibility and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (by difference)	≥ 97.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.