Description

Morphine-D6 is a stable isotope-labeled analog of morphine, where six hydrogen atoms are replaced with deuterium (CAS NO 1334606-17-5). This compound is an essential internal standard for the precise and accurate quantification of morphine in complex biological matrices using advanced analytical techniques. It is primarily required by pharmaceutical research laboratories, forensic toxicology units, and clinical diagnostic facilities engaged in method development and validation.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the accurate measurement of morphine and its metabolites in plasma, serum, and urine.
• Forensic Toxicology: Used in confirmatory testing and method validation for opioid abuse screening and post-mortem analyses to ensure reliable, court-defensible results.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of morphine absorption, distribution, metabolism, and excretion in clinical and pre-clinical research.
• Pharmaceutical Quality Control: Supports the analysis of morphine content and impurity profiling in drug substance and finished product manufacturing.
• Metabolite Identification: Aids in the identification and quantification of morphine-derived metabolites in research on drug metabolism and interactions.
• Reference Standard for Certified Materials: Used in the preparation and certification of calibration standards and quality control materials for clinical laboratories.

Basic Information

Product Name	Morphine-D6
CAS No.	1334606-17-5
Molecular Formula	C₁₇H₁₃D₆NO₃
Molecular Weight	291.36 g/mol
Synonyms	(5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol-d6; Morphine-d6; Deuterated Morphine; [2H6]-Morphine; Morphine (phenyl-d5, N-CD3); Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5α,6α)-, labeled with deuterium
EINECS	Contact for details

Quality Control

Every batch of Morphine-D6 is manufactured and tested to meet the exacting standards required for analytical reference materials. Our quality assurance includes rigorous testing for isotopic purity, chemical purity, and identity confirmation. A comprehensive Certificate of Analysis (COA), detailing results from NMR, HPLC, and MS analyses, is provided with each shipment to ensure traceability and compliance with your laboratory's quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.