Description

Acetyl L-Carnitine-D3 Hydrochloride is a high-purity, deuterium-labeled isotopologue of the endogenous compound acetyl-L-carnitine. This labeled form is essential for advanced research and development, providing a critical tool for pharmacokinetic, metabolic, and tracer studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on neuroscience, metabolic disorders, and drug discovery.

Application

• Internal Standard for Bioanalysis: Serves as a critical reference standard in LC-MS/MS and GC-MS methods for the accurate quantification of acetyl-L-carnitine in biological matrices like plasma, serum, and tissue homogenates.
• Metabolic Tracer Studies: Used in clinical and preclinical research to trace and elucidate the metabolic pathways, distribution, and turnover rates of acetyl-L-carnitine in vivo.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential in pharmaceutical development for studying the absorption, distribution, metabolism, and excretion (ADME) profiles of new drug candidates targeting carnitine-related pathways.
• Neuroscience Research: Applied in studies investigating the role of acetyl-L-carnitine in cognitive function, neuroprotection, mitochondrial energy metabolism, and neurological disorders.
• Stable Isotope Labeling: Employed in the synthesis of more complex labeled compounds or as a probe in mechanistic biochemical studies.
• Quality Control Reference: Used as an analytical standard to validate the purity and identity of non-labeled acetyl-L-carnitine bulk active pharmaceutical ingredients (APIs) and finished products.

Basic Information

Product Name	Acetyl L-Carnitine-D3 Hydrochloride
CAS No.	1334532-17-0
Molecular Formula	C9H15D3ClNO4
Molecular Weight	239.72 g/mol (approximate)
Synonyms	(R)-3-Acetoxy-4-(trimethylammonio-D9)butanoate Hydrochloride; L-Acetylcarnitine-D3 HCl; ALCAR-D3 HCl; Acetyl-L-carnitine (trimethyl-D9) hydrochloride; Acetylcarnitine-D3 hydrochloride; O-Acetyl-L-carnitine-D3 hydrochloride; Levacecarnine-D3 hydrochloride; ST 261-D3
EINECS	Contact for details

Quality Control

Our Acetyl L-Carnitine-D3 Hydrochloride is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including NMR (¹H, ²H, ¹³C) for isotopic enrichment and structural confirmation, HPLC for chemical and isotopic purity, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Allow the sealed container to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Deuterium Enrichment (²H NMR)	≥ 98 atom % D
Purity (HPLC)	≥ 98.0%
Isotopic Purity (HPLC-MS)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.