Description

1-(4-Bromo-2-Fluorophenyl)-2-Methyl-1-Propanol is a high-purity fluorinated and brominated aromatic alcohol building block of significant interest in advanced organic synthesis. This compound matters because it provides a versatile chiral center and reactive handles for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and pesticides, leveraging the fluorine and bromine substituents for bioactivity.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in display technologies.
• Organic Light-Emitting Diodes (OLEDs): Acts as a building block for electron-transport or host materials in OLED fabrication.
• Cross-Coupling Reactions: The bromoaryl moiety makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Asymmetric Synthesis: Utilized in chiral pool synthesis or as a resolving agent due to its stereogenic center.
• Material Science Research: Employed in the development of novel polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	1-(4-Bromo-2-Fluorophenyl)-2-Methyl-1-Propanol
CAS No.	1332651-40-7
Molecular Formula	C10H12BrFO
Molecular Weight	247.11 g/mol
Synonyms	2-Methyl-1-(4-bromo-2-fluorophenyl)-1-propanol; 1-Propanol, 1-(4-bromo-2-fluorophenyl)-2-methyl-; α-(4-Bromo-2-fluorophenyl)-2-methylpropanol; 4-Bromo-2-fluoro-α-(1-hydroxy-1-methylethyl)benzene; (RS)-1-(4-Bromo-2-fluorophenyl)-2-methylpropan-1-ol; 1-(4-Bromo-2-fluorophenyl)-2-methylpropanol; 1-(4-Bromo-2-fluorophenyl)-2-methyl-1-propanol (racemic)
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-2-Fluorophenyl)-2-Methyl-1-Propanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We can supply material compliant with ICH Q7 guidelines for API starting materials upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade) / Contact for racemic specs
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.