Description

2-Chloro-5-Methyl-1H-Benzimidazole Hydrochloride is a high-purity benzimidazole derivative, a crucial building block in advanced organic synthesis. Its value lies in providing a functionalized, halogenated heterocyclic core essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzimidazole-based drug candidates, particularly for antiviral, anticancer, and anti-parasitic applications.
• Agrochemical Research: Serves as a core scaffold for developing new fungicides, herbicides, and plant growth regulators.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis due to its reactive chloro and basic nitrogen sites.
• Material Science Research: Potential monomer or precursor for creating specialty polymers, ligands for catalysis, or organic electronic materials.
• Biochemical Tool Compound: Used in biochemical assays to study enzyme inhibition or receptor binding where the benzimidazole pharmacophore is relevant.

Basic Information

Product Name	2-Chloro-5-Methyl-1H-Benzimidazole Hydrochloride
CAS No.	1332528-75-2
Molecular Formula	C8H8ClN2•HCl
Molecular Weight	205.08 g/mol (Free base: 168.62 g/mol)
Synonyms	2-Chloro-5-methyl-1H-benzimidazole hydrochloride; 5-Methyl-2-chlorobenzimidazole hydrochloride; 1H-Benzimidazole, 2-chloro-5-methyl-, hydrochloride (1:1); 2-Chloro-5-methylbenzimidazole HCl; 2-Chloro-5-methyl-1H-benzo[d]imidazole hydrochloride; Benzimidazole, 2-chloro-5-methyl-, monohydrochloride
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methyl-1H-Benzimidazole Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.