Description

n-Acetyl-S-(Propyl-D7)-L-Cysteine is a stable-isotope labeled derivative of the important biological thiol, L-cysteine. This compound is a critical analytical standard and reagent for quantitative mass spectrometry-based metabolomics and proteomics studies. It is primarily used by researchers and analytical laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors for method development, validation, and as an internal standard for accurate quantification.

Application

• Internal Standard for LC-MS/MS: Serves as a deuterium-labeled internal standard for the precise quantification of S-propyl-L-cysteine, N-acetylcysteine (NAC), and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Biomarker Research: Used in clinical and preclinical studies to investigate pathways related to oxidative stress, glutathione metabolism, and detoxification processes.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential in pharmaceutical R&D for tracing the metabolic fate of drugs containing or affecting cysteine/propyl-thiol pathways, enabling accurate PK/PD modeling.
• Toxicology Studies: Employed in assays to measure exposure to propylating agents or to study the body's antioxidant defense mechanisms.
• High-Purity Reference Material: Provides a certified reference material for calibrating analytical instruments and ensuring data integrity in regulated environments (GLP/GCP).

Basic Information

Product Name	n-Acetyl-S-(Propyl-D7)-L-Cysteine
CAS No.	1331909-69-3
Molecular Formula	C8H8D7NO3S
Molecular Weight	206.30 g/mol (for D7 isotopologue)
Synonyms	N-Acetyl-S-(propyl-d7)-L-cysteine; N-Acetyl-3-[(2,2,3,3,3-pentadeuteriopropyl)sulfanyl]-L-alanine; Acetylcysteine Propyl-d7 Ester; L-Cysteine, N-acetyl-S-(propyl-d7)-; S-(Propyl-d7)-N-acetyl-L-cysteine; Deuterated N-Acetyl-S-propylcysteine; NAC Propyl-d7; Internal Standard for Propyl Mercapturic Acid
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-S-(Propyl-D7)-L-Cysteine is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (D-enrichment), chemical purity, and identity confirmation via orthogonal methods. Our quality commitment ensures consistency and reliability for your most sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.