Description

Ng,Nga€-Dimethyl-L-Arginine-D6 is a stable isotope-labeled analog of the endogenous methylated arginine derivative, asymmetrical dimethylarginine (ADMA). This high-purity deuterated compound is essential for use as an internal standard in quantitative mass spectrometry-based assays, ensuring unparalleled accuracy and reproducibility in analytical workflows. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for precise metabolic profiling and biomarker validation studies.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the accurate quantification of endogenous ADMA and related metabolites in complex biological matrices like plasma, serum, and urine.
• Biomarker Research & Clinical Diagnostics: Enables precise measurement of ADMA levels, a key biomarker associated with endothelial dysfunction, cardiovascular disease, and renal impairment.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Used in drug development to track the metabolism of arginine-related compounds and assess drug efficacy.
• Metabolomics and Proteomics: Facilitates high-fidelity relative and absolute quantification in studies of nitric oxide synthase pathways and protein methylation.
• Method Development & Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with GLP and CLIA guidelines.
• Quality Control & Reference Standard: Acts as a certified reference material for calibrating instruments and verifying assay performance in diagnostic kit manufacturing.

Basic Information

Product Name	Ng,Nga€-Dimethyl-L-Arginine-D6
CAS No.	1331888-08-4
Molecular Formula	C8H12D6N4O2
Molecular Weight	206.27 g/mol
Synonyms	Asymmetric Dimethylarginine-d6; ADMA-d6; NG,NG-Dimethyl-L-arginine-d6; (2S)-2-Amino-5-[(amino-dimethylamino-d6)methylidene]aminopentanoic acid; L-NG,NG-Dimethylarginine-d6; N(G),N(G)-Dimethyl-L-arginine-d6; Isotope Labeled ADMA; Deuterated Asymmetric Dimethylarginine
EINECS	Contact for details

Quality Control

Every batch of Ng,Nga€-Dimethyl-L-Arginine-D6 is manufactured under strict quality systems and undergoes comprehensive analytical characterization to ensure identity, purity, and isotopic enrichment. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from NMR (1H, 13C), mass spectrometry, and HPLC. We adhere to industry best practices suitable for research and diagnostic use, and custom synthesis to meet specific purity or isotopic enrichment requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere after each use to maintain stability and purity. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.