Description

2-Amino-α-(Methoxyimino)-4-Thiazoleacetic Acid-D3 Methyl Ester is a high-purity, deuterium-labeled chemical intermediate of significant importance in analytical and pharmaceutical research. Its core value lies in its use as an internal standard for the precise quantification of cephalosporin antibiotics and related compounds via mass spectrometry. This compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require the highest standards of accuracy and traceability in their analytical methods.

Application

• Primary use as a deuterated internal standard (IS) in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS bioanalytical methods.
• Quantitative analysis and pharmacokinetic studies of cephalosporin antibiotic active pharmaceutical ingredients (APIs) and their metabolites.
• Critical component in method development and validation for regulatory compliance in pharmaceutical R&D.
• Supporting impurity profiling and stability-indicating assays for antibiotic drug substances and finished products.
• Used in forensic and anti-doping analysis for the detection of antibiotic residues.
• Facilitates research into the metabolism and environmental fate of thiazole-based pharmaceutical compounds.

Basic Information

Product Name	2-Amino-α-(Methoxyimino)-4-Thiazoleacetic Acid-D3 Methyl Ester
CAS No.	1331670-10-0
Molecular Formula	C7H7D3N3O3S
Molecular Weight	217.23 g/mol
Synonyms	2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic-2,2,2-d3 acid methyl ester; Methyl 2-(2-amino-4-thiazolyl)glyoxylate-2,2,2-d3 O-methyloxime; (Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic-2,2,2-d3 acid methyl ester; Deuterated Cephalosporin Side Chain; AMTA-D3 Methyl Ester; 2-Aminothiazol-4-yl-2-methoxyimino acetate-d3 methyl ester; Deuterium Labeled 7-ACA Side Chain Derivative
EINECS	Contact for details

Quality Control

Every batch of our 2-Amino-α-(Methoxyimino)-4-Thiazoleacetic Acid-D3 Methyl Ester is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR (¹H, ¹³C), Mass Spectrometry, and HPLC. A Certificate of Analysis (COA) detailing purity, assay, isotopic purity (D-enrichment), and identification is provided with each shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.